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Methadone may possibly bring about critical hypotension such as orthostatic hypotension and syncope in ambulatory individuals. Watch in the course of initiation and/or titration of methadone.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​